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Development of paroxysmal nocturnal hemoglobinuria in CALR-positive myeloproliferative neoplasm
Paroxysmal nocturnal hemoglobinuria (PNH), a disease characterized by intravascular hemolysis, thrombosis, and bone marrow failure, is associated with mutations in the PIG-A gene, resulting in a deficiency of glycosylphosphatidylinositol-anchored proteins. Many hypotheses have been posed as to wheth...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892839/ https://www.ncbi.nlm.nih.gov/pubmed/27313483 http://dx.doi.org/10.2147/JBM.S103473 |