CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson's disease

The cannabinoid (CB2) receptor type 2 has been proposed to prevent the degeneration of dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. However, the mechanisms underlying CB2 receptor-mediated neuroprotection in MPTP mice have not been elucidated. The mechanisms...

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Detalles Bibliográficos
Autores principales: Chung, Young C, Shin, Won-Ho, Baek, Jeong Y, Cho, Eun J, Baik, Hyung H, Kim, Sang R, Won, So-Yoon, Jin, Byung K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892852/
https://www.ncbi.nlm.nih.gov/pubmed/27534533
http://dx.doi.org/10.1038/emm.2015.100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892852/
https://www.ncbi.nlm.nih.gov/pubmed/27534533
http://dx.doi.org/10.1038/emm.2015.100

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