Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1

Cancer cells typically display increased rates of aerobic glycolysis that are correlated with tumor aggressiveness and a poor prognosis. Targeting the glycolytic pathway has emerged as an attractive therapeutic route mainly because it should spare normal cells. Here, we evaluate the effects of combi...

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Detalles Bibliográficos
Autores principales: Graham, Regina M, Hernandez, Fiorela, Puerta, Nataly, De Angulo, Guillermo, Webster, Keith A, Vanni, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892869/
https://www.ncbi.nlm.nih.gov/pubmed/26891914
http://dx.doi.org/10.1038/emm.2015.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892869/
https://www.ncbi.nlm.nih.gov/pubmed/26891914
http://dx.doi.org/10.1038/emm.2015.116

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