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The autoimmunity-associated gene RGS1 affects the frequency of T follicular helper cells

RGS1 (regulator of G-protein signaling 1) has been associated with multiple autoimmune disorders including type 1 diabetes. RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization of T and B cells in lymphoid organs. To explore how RGS1 variation contributes to...

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Detalles Bibliográficos
Autores principales: Caballero-Franco, Celia, Kissler, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892947/
https://www.ncbi.nlm.nih.gov/pubmed/27029527
http://dx.doi.org/10.1038/gene.2016.16