Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis

OBJECTIVES: Tropomyosin receptor kinase A (TrkA) mediates nociceptor sensitisation by nerve growth factor (NGF), but it is unknown whether selective TrkA inhibition will be an effective strategy for treating osteoarthritis (OA) pain. We determined the effects of a TrkA inhibitor (AR786) on pain beha...

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Detalles Bibliográficos
Autores principales: Nwosu, Lilian N, Mapp, Paul I, Chapman, Victoria, Walsh, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893148/
https://www.ncbi.nlm.nih.gov/pubmed/26286016
http://dx.doi.org/10.1136/annrheumdis-2014-207203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893148/
https://www.ncbi.nlm.nih.gov/pubmed/26286016
http://dx.doi.org/10.1136/annrheumdis-2014-207203

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