DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor

Transplantation of DA neurons is actively pursued as a restorative therapy in Parkinson’s disease (PD). Pioneering clinical trials using transplants of fetal DA neuroblasts have given promising results, although a number of patients have developed graft-induced dyskinesias (GIDs), and the mechanism...

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Detalles Bibliográficos
Autores principales: Aldrin-Kirk, Patrick, Heuer, Andreas, Wang, Gang, Mattsson, Bengt, Lundblad, Martin, Parmar, Malin, Björklund, Tomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893163/
https://www.ncbi.nlm.nih.gov/pubmed/27161524
http://dx.doi.org/10.1016/j.neuron.2016.04.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893163/
https://www.ncbi.nlm.nih.gov/pubmed/27161524
http://dx.doi.org/10.1016/j.neuron.2016.04.017

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