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Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study

BACKGROUND: The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. METHODS: In this case–control study, we included a total of 146 patients with DR and...

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Autores principales: Alcubierre, Nuria, Navarrete-Muñoz, Eva M., Rubinat, Esther, Falguera, Mireia, Valls, Joan, Traveset, Alicia, Vilanova, Maria-Belen, Marsal, Josep Ramon, Hernandez, Marta, Granado-Casas, Minerva, Martinez-Gonzalez, Dolores, Jurjo, Carmen, Franch-Nadal, Josep, Vioque, Jesús, Mauricio, Didac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893240/
https://www.ncbi.nlm.nih.gov/pubmed/27274760
http://dx.doi.org/10.1186/s12986-016-0099-5
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author Alcubierre, Nuria
Navarrete-Muñoz, Eva M.
Rubinat, Esther
Falguera, Mireia
Valls, Joan
Traveset, Alicia
Vilanova, Maria-Belen
Marsal, Josep Ramon
Hernandez, Marta
Granado-Casas, Minerva
Martinez-Gonzalez, Dolores
Jurjo, Carmen
Franch-Nadal, Josep
Vioque, Jesús
Mauricio, Didac
author_facet Alcubierre, Nuria
Navarrete-Muñoz, Eva M.
Rubinat, Esther
Falguera, Mireia
Valls, Joan
Traveset, Alicia
Vilanova, Maria-Belen
Marsal, Josep Ramon
Hernandez, Marta
Granado-Casas, Minerva
Martinez-Gonzalez, Dolores
Jurjo, Carmen
Franch-Nadal, Josep
Vioque, Jesús
Mauricio, Didac
author_sort Alcubierre, Nuria
collection PubMed
description BACKGROUND: The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. METHODS: In this case–control study, we included a total of 146 patients with DR and 148 without DR. The intake of macronutrient was evaluated using a validated food frequency questionnaire. We used logistic regression adjusted for sex, age, diabetes duration, energy intake, educational level, physical activity, waist circumference, systolic blood pressure, high-density lipoprotein cholesterol and diabetes treatment, to estimate odds ratio (ORs) of DR. RESULTS: Patients with DR had significantly lower intake of fibre, monounsaturated fatty acids (MUFA), and palmitic and oleic acid. Inverse associations were observed between MUFA and oleic acid intake in DR. Subjects with intermediate and high MUFA intake were less likely to have DR than those with lower MUFA intake, with ORs of 0.46 (95 % CI: 0.22–0.93) and 0.42 (95 % CI: 0.18–0.97), respectively. Similarly, intermediate and high oleic acid intake were associated with reduced DR frequency compared with low oleic acid intake, with OR values of 0.48 (95 % CI: 0.23–0.97) and 0.37 (95 % CI: 0.16–0.85), respectively. These associations were stronger in patients with a longer diabetes duration. CONCLUSION: In type 2 diabetes mellitus, MUFA and oleic acid intake were inversely associated with DR.
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spelling pubmed-48932402016-06-05 Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study Alcubierre, Nuria Navarrete-Muñoz, Eva M. Rubinat, Esther Falguera, Mireia Valls, Joan Traveset, Alicia Vilanova, Maria-Belen Marsal, Josep Ramon Hernandez, Marta Granado-Casas, Minerva Martinez-Gonzalez, Dolores Jurjo, Carmen Franch-Nadal, Josep Vioque, Jesús Mauricio, Didac Nutr Metab (Lond) Research BACKGROUND: The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. METHODS: In this case–control study, we included a total of 146 patients with DR and 148 without DR. The intake of macronutrient was evaluated using a validated food frequency questionnaire. We used logistic regression adjusted for sex, age, diabetes duration, energy intake, educational level, physical activity, waist circumference, systolic blood pressure, high-density lipoprotein cholesterol and diabetes treatment, to estimate odds ratio (ORs) of DR. RESULTS: Patients with DR had significantly lower intake of fibre, monounsaturated fatty acids (MUFA), and palmitic and oleic acid. Inverse associations were observed between MUFA and oleic acid intake in DR. Subjects with intermediate and high MUFA intake were less likely to have DR than those with lower MUFA intake, with ORs of 0.46 (95 % CI: 0.22–0.93) and 0.42 (95 % CI: 0.18–0.97), respectively. Similarly, intermediate and high oleic acid intake were associated with reduced DR frequency compared with low oleic acid intake, with OR values of 0.48 (95 % CI: 0.23–0.97) and 0.37 (95 % CI: 0.16–0.85), respectively. These associations were stronger in patients with a longer diabetes duration. CONCLUSION: In type 2 diabetes mellitus, MUFA and oleic acid intake were inversely associated with DR. BioMed Central 2016-06-04 /pmc/articles/PMC4893240/ /pubmed/27274760 http://dx.doi.org/10.1186/s12986-016-0099-5 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Alcubierre, Nuria
Navarrete-Muñoz, Eva M.
Rubinat, Esther
Falguera, Mireia
Valls, Joan
Traveset, Alicia
Vilanova, Maria-Belen
Marsal, Josep Ramon
Hernandez, Marta
Granado-Casas, Minerva
Martinez-Gonzalez, Dolores
Jurjo, Carmen
Franch-Nadal, Josep
Vioque, Jesús
Mauricio, Didac
Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
title Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
title_full Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
title_fullStr Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
title_full_unstemmed Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
title_short Association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
title_sort association of low oleic acid intake with diabetic retinopathy in type 2 diabetic patients: a case–control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893240/
https://www.ncbi.nlm.nih.gov/pubmed/27274760
http://dx.doi.org/10.1186/s12986-016-0099-5
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