Adaptive and Acquired Resistance to EGFR Inhibitors Converge on the MAPK Pathway

Both adaptive and acquired resistance significantly limits the efficacy of the epidermal growth factor receptor (EGFR) kinase inhibitors. However, the distinct or common mechanisms of adaptive and acquired resistance have not been fully characterized. Here, through systematic modeling of erlotinib r...

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Detalles Bibliográficos
Autores principales: Ma, Pengfei, Fu, Yujie, Chen, Minjiang, Jing, Ying, Wu, Jie, Li, Ke, Shen, Ying, Gao, Jian-Xin, Wang, Mengzhao, Zhao, Xiaojing, Zhuang, Guanglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893648/
https://www.ncbi.nlm.nih.gov/pubmed/27279914
http://dx.doi.org/10.7150/thno.14409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893648/
https://www.ncbi.nlm.nih.gov/pubmed/27279914
http://dx.doi.org/10.7150/thno.14409

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