Ca(2+) is a key factor in α-synuclein-induced neurotoxicity

Aggregation of α-synuclein leads to the formation of oligomeric intermediates that can interact with membranes to form pores. However, it is unknown how this leads to cell toxicity in Parkinson's disease. We investigated the species-specific effects of α-synuclein on Ca(2+) signalling in primar...

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Detalles Bibliográficos
Autores principales: Angelova, Plamena R., Ludtmann, Marthe H. R., Horrocks, Mathew H., Negoda, Alexander, Cremades, Nunilo, Klenerman, David, Dobson, Christopher M., Wood, Nicholas W., Pavlov, Evgeny V., Gandhi, Sonia, Abramov, Andrey Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893653/
https://www.ncbi.nlm.nih.gov/pubmed/26989132
http://dx.doi.org/10.1242/jcs.180737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893653/
https://www.ncbi.nlm.nih.gov/pubmed/26989132
http://dx.doi.org/10.1242/jcs.180737

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