Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion

Exogenous androgenic steroids applied to pregnant sheep programmes a PCOS-like phenotype in female offspring. Via ultrasound guidance we applied steroids directly to ovine fetuses at d62 and d82 of gestation, and examined fetal (day 90 gestation) and postnatal (11 months old) pancreatic structure an...

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Detalles Bibliográficos
Autores principales: Ramaswamy, S., Grace, C., Mattei, A. A., Siemienowicz, K., Brownlee, W., MacCallum, J., McNeilly, A. S., Duncan, W. C., Rae, M. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893678/
https://www.ncbi.nlm.nih.gov/pubmed/27265420
http://dx.doi.org/10.1038/srep27408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893678/
https://www.ncbi.nlm.nih.gov/pubmed/27265420
http://dx.doi.org/10.1038/srep27408

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