Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia

HIF-1 (hypoxia-inducible factor-1) regulates the expression of more than 70 genes involved in angiogenesis, tumor growth, metastasis, chemoresistance, and radioresistance. Thus, there is growing interest in using HIF-1 inhibitors as anticancer drugs. Docetaxel, a Food and Drug Administration-approve...

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Detalles Bibliográficos
Autores principales: Oh, Eun-Taex, Kim, Chan Woo, Kim, Soo Jung, Lee, Jae-Seon, Hong, Soon-Sun, Park, Heon Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893693/
https://www.ncbi.nlm.nih.gov/pubmed/27263528
http://dx.doi.org/10.1038/srep27382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893693/
https://www.ncbi.nlm.nih.gov/pubmed/27263528
http://dx.doi.org/10.1038/srep27382

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