High-contrast grating resonators for label-free detection of disease biomarkers

A label-free optical biosensor is described that employs a silicon-based high-contrast grating (HCG) resonator with a spectral linewidth of ~500 pm that is sensitive to ligand-induced changes in surface properties. The device is used to generate thermodynamic and kinetic data on surface-attached ant...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Tianbo, Kan, Shu, Marriott, Gerard, Chang-Hasnain, Connie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893738/
https://www.ncbi.nlm.nih.gov/pubmed/27265624
http://dx.doi.org/10.1038/srep27482
Descripción
Sumario:A label-free optical biosensor is described that employs a silicon-based high-contrast grating (HCG) resonator with a spectral linewidth of ~500 pm that is sensitive to ligand-induced changes in surface properties. The device is used to generate thermodynamic and kinetic data on surface-attached antibodies with their respective antigens. The device can detect serum cardiac troponin I, a biomarker of cardiac disease to 100 pg/ml within 4 mins, which is faster, and as sensitive as current enzyme-linked immuno-assays for cTnI.

Ejemplares similares