High-contrast grating resonators for label-free detection of disease biomarkers

A label-free optical biosensor is described that employs a silicon-based high-contrast grating (HCG) resonator with a spectral linewidth of ~500 pm that is sensitive to ligand-induced changes in surface properties. The device is used to generate thermodynamic and kinetic data on surface-attached ant...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Tianbo, Kan, Shu, Marriott, Gerard, Chang-Hasnain, Connie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893738/
https://www.ncbi.nlm.nih.gov/pubmed/27265624
http://dx.doi.org/10.1038/srep27482
_version_ 1782435615857442816
author Sun, Tianbo
Kan, Shu
Marriott, Gerard
Chang-Hasnain, Connie
author_facet Sun, Tianbo
Kan, Shu
Marriott, Gerard
Chang-Hasnain, Connie
author_sort Sun, Tianbo
collection PubMed
description A label-free optical biosensor is described that employs a silicon-based high-contrast grating (HCG) resonator with a spectral linewidth of ~500 pm that is sensitive to ligand-induced changes in surface properties. The device is used to generate thermodynamic and kinetic data on surface-attached antibodies with their respective antigens. The device can detect serum cardiac troponin I, a biomarker of cardiac disease to 100 pg/ml within 4 mins, which is faster, and as sensitive as current enzyme-linked immuno-assays for cTnI.
format Online
Article
Text
id pubmed-4893738
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-48937382016-06-10 High-contrast grating resonators for label-free detection of disease biomarkers Sun, Tianbo Kan, Shu Marriott, Gerard Chang-Hasnain, Connie Sci Rep Article A label-free optical biosensor is described that employs a silicon-based high-contrast grating (HCG) resonator with a spectral linewidth of ~500 pm that is sensitive to ligand-induced changes in surface properties. The device is used to generate thermodynamic and kinetic data on surface-attached antibodies with their respective antigens. The device can detect serum cardiac troponin I, a biomarker of cardiac disease to 100 pg/ml within 4 mins, which is faster, and as sensitive as current enzyme-linked immuno-assays for cTnI. Nature Publishing Group 2016-06-06 /pmc/articles/PMC4893738/ /pubmed/27265624 http://dx.doi.org/10.1038/srep27482 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Sun, Tianbo
Kan, Shu
Marriott, Gerard
Chang-Hasnain, Connie
High-contrast grating resonators for label-free detection of disease biomarkers
title High-contrast grating resonators for label-free detection of disease biomarkers
title_full High-contrast grating resonators for label-free detection of disease biomarkers
title_fullStr High-contrast grating resonators for label-free detection of disease biomarkers
title_full_unstemmed High-contrast grating resonators for label-free detection of disease biomarkers
title_short High-contrast grating resonators for label-free detection of disease biomarkers
title_sort high-contrast grating resonators for label-free detection of disease biomarkers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893738/
https://www.ncbi.nlm.nih.gov/pubmed/27265624
http://dx.doi.org/10.1038/srep27482
work_keys_str_mv AT suntianbo highcontrastgratingresonatorsforlabelfreedetectionofdiseasebiomarkers
AT kanshu highcontrastgratingresonatorsforlabelfreedetectionofdiseasebiomarkers
AT marriottgerard highcontrastgratingresonatorsforlabelfreedetectionofdiseasebiomarkers
AT changhasnainconnie highcontrastgratingresonatorsforlabelfreedetectionofdiseasebiomarkers

Ejemplares similares