Validation of a commercially available anti-REDD1 antibody using RNA interference and REDD1-/- mouse embryonic fibroblasts

REDD1 is a transcriptional target gene of p53 and HIF-1, and an inhibitor of mTOR (mechanistic target of rapamycin) complex 1 (mTORC1)-signaling through PP2A-dependent interaction, making it an important convergence point of both tumor suppression and cell growth pathways. In accordance with this po...

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Detalles Bibliográficos
Autores principales: Grainger, Deborah L., Kutzler, Lydia, Rannels, Sharon L., Kimball, Scot R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Antibody Validation Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893971/
https://www.ncbi.nlm.nih.gov/pubmed/27335637
http://dx.doi.org/10.12688/f1000research.7691.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893971/
https://www.ncbi.nlm.nih.gov/pubmed/27335637
http://dx.doi.org/10.12688/f1000research.7691.1

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