The structural basis of an NADP(+)-independent dithiol oxidase in FK228 biosynthesis

The disulfide bond is unusual in natural products and critical for thermal stability, cell permeability and bioactivity. DepH from Chromobacterium violaceum No. 968 is an FAD-dependent enzyme responsible for catalyzing the disulfide bond formation of FK228, an anticancer prodrug approved for the tre...

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Detalles Bibliográficos
Autores principales: Li, Jie, Wang, Cheng, Zhang, Zhi-Min, Cheng, Yi-Qiang, Zhou, Jiahai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894451/
https://www.ncbi.nlm.nih.gov/pubmed/24553401
http://dx.doi.org/10.1038/srep04145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894451/
https://www.ncbi.nlm.nih.gov/pubmed/24553401
http://dx.doi.org/10.1038/srep04145

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