Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation

DNA 5-methylcytosine is a dynamic epigenetic mark which plays important roles in development and disease. In the Tet-Tdg demethylation pathway, methylated cytosine is iteratively oxidized by Tet dioxygenases and unmodified cytosine is restored via thymine DNA glycosylase (Tdg). Here we show that hum...

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Detalles Bibliográficos
Autores principales: Schomacher, Lars, Han, Dandan, Musheev, Michael U., Arab, Khelifa, Kienhöfer, Sabine, von Seggern, Annika, Niehrs, Christof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894546/
https://www.ncbi.nlm.nih.gov/pubmed/26751644
http://dx.doi.org/10.1038/nsmb.3151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894546/
https://www.ncbi.nlm.nih.gov/pubmed/26751644
http://dx.doi.org/10.1038/nsmb.3151

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