Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture

The cellular response to DNA double strand breaks (DSBs) is a multifaceted signaling program that centers on post-translational modifications including phosphorylation, ubiquitylation and SUMOylation. In this review we discuss how ubiquitin and SUMO orchestrate the recognition of DSBs and explore ho...

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Detalles Bibliográficos
Autores principales: Harding, Shane M., Greenberg, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894868/
https://www.ncbi.nlm.nih.gov/pubmed/27375678
http://dx.doi.org/10.3389/fgene.2016.00103
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author Harding, Shane M.
Greenberg, Roger A.
author_facet Harding, Shane M.
Greenberg, Roger A.
author_sort Harding, Shane M.
collection PubMed
description The cellular response to DNA double strand breaks (DSBs) is a multifaceted signaling program that centers on post-translational modifications including phosphorylation, ubiquitylation and SUMOylation. In this review we discuss how ubiquitin and SUMO orchestrate the recognition of DSBs and explore how this influences chromatin organization. We discuss functional outcomes of this response including transcriptional silencing and how pre-existing chromatin states may control the DSB response and the maintenance of genomic stability.
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spelling pubmed-48948682016-07-01 Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture Harding, Shane M. Greenberg, Roger A. Front Genet Genetics The cellular response to DNA double strand breaks (DSBs) is a multifaceted signaling program that centers on post-translational modifications including phosphorylation, ubiquitylation and SUMOylation. In this review we discuss how ubiquitin and SUMO orchestrate the recognition of DSBs and explore how this influences chromatin organization. We discuss functional outcomes of this response including transcriptional silencing and how pre-existing chromatin states may control the DSB response and the maintenance of genomic stability. Frontiers Media S.A. 2016-06-07 /pmc/articles/PMC4894868/ /pubmed/27375678 http://dx.doi.org/10.3389/fgene.2016.00103 Text en Copyright © 2016 Harding and Greenberg. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Harding, Shane M.
Greenberg, Roger A.
Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture
title Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture
title_full Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture
title_fullStr Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture
title_full_unstemmed Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture
title_short Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture
title_sort choreographing the double strand break response: ubiquitin and sumo control of nuclear architecture
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894868/
https://www.ncbi.nlm.nih.gov/pubmed/27375678
http://dx.doi.org/10.3389/fgene.2016.00103
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