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A method to rapidly create protein aggregates in living cells

The accumulation of protein aggregates is a common pathological hallmark of many neurodegenerative diseases. However, we do not fully understand how aggregates are formed or the complex network of chaperones, proteasomes and other regulatory factors involved in their clearance. Here, we report a che...

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Detalles Bibliográficos
Autores principales: Miyazaki, Yusuke, Mizumoto, Kota, Dey, Gautam, Kudo, Takamasa, Perrino, John, Chen, Ling-chun, Meyer, Tobias, Wandless, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894968/
https://www.ncbi.nlm.nih.gov/pubmed/27229621
http://dx.doi.org/10.1038/ncomms11689