A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair

Inhibition of the Wnt antagonist sclerostin increases bone mass in patients with osteoporosis and in preclinical animal models. Here we show increased levels of the Wnt antagonist Dickkopf-1 (DKK-1) in animals treated with sclerostin antibody, suggesting a negative feedback mechanism that limits Wnt...

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Detalles Bibliográficos
Autores principales: Florio, Monica, Gunasekaran, Kannan, Stolina, Marina, Li, Xiaodong, Liu, Ling, Tipton, Barbara, Salimi-Moosavi, Hossein, Asuncion, Franklin J., Li, Chaoyang, Sun, Banghua, Tan, Hong Lin, Zhang, Li, Han, Chun-Ya, Case, Ryan, Duguay, Amy N., Grisanti, Mario, Stevens, Jennitte, Pretorius, James K., Pacheco, Efrain, Jones, Heidi, Chen, Qing, Soriano, Brian D., Wen, Jie, Heron, Brenda, Jacobsen, Frederick W., Brisan, Emil, Richards, William G., Ke, Hua Zhu, Ominsky, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894982/
https://www.ncbi.nlm.nih.gov/pubmed/27230681
http://dx.doi.org/10.1038/ncomms11505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894982/
https://www.ncbi.nlm.nih.gov/pubmed/27230681
http://dx.doi.org/10.1038/ncomms11505

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