The well-accepted notion that gene amplification contributes to increased expression still remains, after all these years, a reasonable but unproven assumption

“Gene amplification causes overexpression” is a longstanding and well-accepted concept in cancer genetics. However, raking the whole literature, we find only statistical analyses showing a positive correlation between gene copy number and expression level, but do not find convincing experimental cor...

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Detalles Bibliográficos
Autores principales: Jia, Yuping, Chen, Lichan, Jia, Qingwen, Dou, Xixi, Xu, Ningzhi, Liao, Dezhong Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895059/
https://www.ncbi.nlm.nih.gov/pubmed/27298590
http://dx.doi.org/10.4103/1477-3163.182809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895059/
https://www.ncbi.nlm.nih.gov/pubmed/27298590
http://dx.doi.org/10.4103/1477-3163.182809

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