Peptide aromatic interactions modulated by fluorinated residues: Synthesis, structure and biological activity of Somatostatin analogs containing 3-(3′,5′difluorophenyl)-alanine

Somatostatin is a 14-residue peptide hormone that regulates the endocrine system by binding to five G-protein-coupled receptors (SSTR1–5). We have designed six new Somatostatin analogs with L-3-(3′,5′-difluorophenyl)-alanine (Dfp) as a substitute of Phe and studied the effect of an electron-poor aro...

Descripción completa

Detalles Bibliográficos
Autores principales: Martín-Gago, Pablo, Rol, Álvaro, Todorovski, Toni, Aragón, Eric, Martin-Malpartida, Pau, Verdaguer, Xavier, Vallès Miret, Mariona, Fernández-Carneado, Jimena, Ponsati, Berta, Macias, Maria J., Riera, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895178/
https://www.ncbi.nlm.nih.gov/pubmed/27271737
http://dx.doi.org/10.1038/srep27285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895178/
https://www.ncbi.nlm.nih.gov/pubmed/27271737
http://dx.doi.org/10.1038/srep27285

Ejemplares similares