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Thyrostimulin-TSHR signaling promotes the proliferation of NIH:OVCAR-3 ovarian cancer cells via trans-regulation of the EGFR pathway

Gonadotropin signaling plays an indispensable role in ovarian cancer progression. We previously have demonstrated that thyrostimulin and thyroid-stimulating hormone receptor (TSHR), the most ancient glycoprotein hormone and receptor pair that evolved much earlier than the gonadotropin systems, co-ex...

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Detalles Bibliográficos
Autores principales: Huang, Wei-Lin, Li, Zhongyou, Lin, Ting-Yu, Wang, Sheng-Wen, Wu, Fang-Ju, Luo, Ching-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895341/
https://www.ncbi.nlm.nih.gov/pubmed/27273257
http://dx.doi.org/10.1038/srep27471