Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10

RNA is an important target for chemical probes of function and lead therapeutics; however, it is difficult to target with small molecules. One approach to tackle this problem is to identify compounds that target RNA structures and utilize them to multivalently target RNA. Here we show that small mol...

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Detalles Bibliográficos
Autores principales: Yang, Wang-Yong, Gao, Rui, Southern, Mark, Sarkar, Partha S., Disney, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895354/
https://www.ncbi.nlm.nih.gov/pubmed/27248057
http://dx.doi.org/10.1038/ncomms11647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895354/
https://www.ncbi.nlm.nih.gov/pubmed/27248057
http://dx.doi.org/10.1038/ncomms11647

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