UbiSite: incorporating two-layered machine learning method with substrate motifs to predict ubiquitin-conjugation site on lysines

BACKGROUND: The conjugation of ubiquitin to a substrate protein (protein ubiquitylation), which involves a sequential process – E1 activation, E2 conjugation and E3 ligation, is crucial to the regulation of protein function and activity in eukaryotes. This ubiquitin-conjugation process typically bin...

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Detalles Bibliográficos
Autores principales: Huang, Chien-Hsun, Su, Min-Gang, Kao, Hui-Ju, Jhong, Jhih-Hua, Weng, Shun-Long, Lee, Tzong-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895383/
https://www.ncbi.nlm.nih.gov/pubmed/26818456
http://dx.doi.org/10.1186/s12918-015-0246-z