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Pro‐tumorigenic Effects of Transforming Growth Factor Beta 1 in Canine Osteosarcoma

BACKGROUND: Transforming growth factor beta 1 (TGFβ1) is a pleiotropic cytokine that contributes to reparative skeletal remodeling by inducing osteoblast proliferation, migration, and angiogenesis. Organic bone matrix is the largest bodily reservoir for latent TGFβ1, and active osteoblasts express c...

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Detalles Bibliográficos
Autores principales: Portela, R.F., Fadl‐Alla, B.A., Pondenis, H.C., Byrum, M.L., Garrett, L.D., Wycislo, K.L., Borst, L.B., Fan, T.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895458/
https://www.ncbi.nlm.nih.gov/pubmed/24684686
http://dx.doi.org/10.1111/jvim.12348