Evaluation of rate law approximations in bottom-up kinetic models of metabolism

BACKGROUND: The mechanistic description of enzyme kinetics in a dynamic model of metabolism requires specifying the numerical values of a large number of kinetic parameters. The parameterization challenge is often addressed through the use of simplifying approximations to form reaction rate laws wit...

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Detalles Bibliográficos
Autores principales: Du, Bin, Zielinski, Daniel C., Kavvas, Erol S., Dräger, Andreas, Tan, Justin, Zhang, Zhen, Ruggiero, Kayla E., Arzumanyan, Garri A., Palsson, Bernhard O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895898/
https://www.ncbi.nlm.nih.gov/pubmed/27266508
http://dx.doi.org/10.1186/s12918-016-0283-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895898/
https://www.ncbi.nlm.nih.gov/pubmed/27266508
http://dx.doi.org/10.1186/s12918-016-0283-2

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