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Evaluation of rate law approximations in bottom-up kinetic models of metabolism
BACKGROUND: The mechanistic description of enzyme kinetics in a dynamic model of metabolism requires specifying the numerical values of a large number of kinetic parameters. The parameterization challenge is often addressed through the use of simplifying approximations to form reaction rate laws wit...
Autores principales: | Du, Bin, Zielinski, Daniel C., Kavvas, Erol S., Dräger, Andreas, Tan, Justin, Zhang, Zhen, Ruggiero, Kayla E., Arzumanyan, Garri A., Palsson, Bernhard O. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895898/ https://www.ncbi.nlm.nih.gov/pubmed/27266508 http://dx.doi.org/10.1186/s12918-016-0283-2 |
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