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Num1 anchors mitochondria to the plasma membrane via two domains with different lipid binding specificities
The mitochondria–ER cortex anchor (MECA) is required for proper mitochondrial distribution and functions by tethering mitochondria to the plasma membrane. The core component of MECA is the multidomain protein Num1, which assembles into clusters at the cell cortex. We show Num1 adopts an extended, po...
Autores principales: | Ping, Holly A., Kraft, Lauren M., Chen, WeiTing, Nilles, Amy E., Lackner, Laura L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896055/ https://www.ncbi.nlm.nih.gov/pubmed/27241910 http://dx.doi.org/10.1083/jcb.201511021 |
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