Mutations Designed by Ensemble Defect to Misfold Conserved RNA Structures of Influenza A Segments 7 and 8 Affect Splicing and Attenuate Viral Replication in Cell Culture

Influenza A virus is a significant public health threat, but little is understood about the viral RNA structure and function. Current vaccines and therapeutic options to control influenza A virus infections are mostly protein-centric and of limited effectiveness. Here, we report using an ensemble de...

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Detalles Bibliográficos
Autores principales: Jiang, Tian, Nogales, Aitor, Baker, Steven F, Martinez-Sobrido, Luis, Turner, Douglas H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896458/
https://www.ncbi.nlm.nih.gov/pubmed/27272307
http://dx.doi.org/10.1371/journal.pone.0156906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896458/
https://www.ncbi.nlm.nih.gov/pubmed/27272307
http://dx.doi.org/10.1371/journal.pone.0156906

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