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An Algorithm to Identify Target-Selective Ligands – A Case Study of 5-HT7/5-HT1A Receptor Selectivity
A computational procedure to search for selective ligands for structurally related protein targets was developed and verified for serotonergic 5-HT(7)/5-HT(1A) receptor ligands. Starting from a set of compounds with annotated activity at both targets (grouped into four classes according to their act...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896471/ https://www.ncbi.nlm.nih.gov/pubmed/27271158 http://dx.doi.org/10.1371/journal.pone.0156986 |