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An Algorithm to Identify Target-Selective Ligands – A Case Study of 5-HT7/5-HT1A Receptor Selectivity

A computational procedure to search for selective ligands for structurally related protein targets was developed and verified for serotonergic 5-HT(7)/5-HT(1A) receptor ligands. Starting from a set of compounds with annotated activity at both targets (grouped into four classes according to their act...

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Detalles Bibliográficos
Autores principales:	Kurczab, Rafał, Canale, Vittorio, Zajdel, Paweł, Bojarski, Andrzej J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896471/ https://www.ncbi.nlm.nih.gov/pubmed/27271158 http://dx.doi.org/10.1371/journal.pone.0156986

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