An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK

A broadly known method to stimulate the growth potential of axons is to elevate intracellular levels of cAMP, however the cellular pathway(s) that mediate this are not known. Here we identify the Dual Leucine-zipper Kinase (DLK, Wnd in Drosophila) as a critical target and effector of cAMP in injured...

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Detalles Bibliográficos
Autores principales: Hao, Yan, Frey, Erin, Yoon, Choya, Wong, Hetty, Nestorovski, Douglas, Holzman, Lawrence B, Giger, Roman J, DiAntonio, Aaron, Collins, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896747/
https://www.ncbi.nlm.nih.gov/pubmed/27268300
http://dx.doi.org/10.7554/eLife.14048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896747/
https://www.ncbi.nlm.nih.gov/pubmed/27268300
http://dx.doi.org/10.7554/eLife.14048

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