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An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK
A broadly known method to stimulate the growth potential of axons is to elevate intracellular levels of cAMP, however the cellular pathway(s) that mediate this are not known. Here we identify the Dual Leucine-zipper Kinase (DLK, Wnd in Drosophila) as a critical target and effector of cAMP in injured...
Autores principales: | Hao, Yan, Frey, Erin, Yoon, Choya, Wong, Hetty, Nestorovski, Douglas, Holzman, Lawrence B, Giger, Roman J, DiAntonio, Aaron, Collins, Catherine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896747/ https://www.ncbi.nlm.nih.gov/pubmed/27268300 http://dx.doi.org/10.7554/eLife.14048 |
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