Cargando…
Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy
This commentary describes a rationale for the use of breakthrough viruses from clinical trial participants to assess neutralizing antibodies as a correlate of HIV-1 vaccine efficacy. The rationale is based on principles of a genetic sieve analysis, where the 2 analyses may be cooperative for delinea...
| Autor principal: | |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896798/ https://www.ncbi.nlm.nih.gov/pubmed/25424964 http://dx.doi.org/10.4161/hv.28950 |
| _version_ | 1782436040343027712 |
|---|---|
| author | Montefiori, David C |
| author_facet | Montefiori, David C |
| author_sort | Montefiori, David C |
| collection | PubMed |
| description | This commentary describes a rationale for the use of breakthrough viruses from clinical trial participants to assess neutralizing antibodies as a correlate of HIV-1 vaccine efficacy. The rationale is based on principles of a genetic sieve analysis, where the 2 analyses may be cooperative for delineating neutralizing antibodies as a mechanistic correlate of protection. |
| format | Online Article Text |
| id | pubmed-4896798 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-48967982016-06-24 Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy Montefiori, David C Hum Vaccin Immunother Commentary This commentary describes a rationale for the use of breakthrough viruses from clinical trial participants to assess neutralizing antibodies as a correlate of HIV-1 vaccine efficacy. The rationale is based on principles of a genetic sieve analysis, where the 2 analyses may be cooperative for delineating neutralizing antibodies as a mechanistic correlate of protection. Taylor & Francis 2014-05-01 /pmc/articles/PMC4896798/ /pubmed/25424964 http://dx.doi.org/10.4161/hv.28950 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| spellingShingle | Commentary Montefiori, David C Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy |
| title | Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy |
| title_full | Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy |
| title_fullStr | Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy |
| title_full_unstemmed | Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy |
| title_short | Importance of neutralization sieve analyses when seeking correlates of HIV-1 vaccine efficacy |
| title_sort | importance of neutralization sieve analyses when seeking correlates of hiv-1 vaccine efficacy |
| topic | Commentary |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896798/ https://www.ncbi.nlm.nih.gov/pubmed/25424964 http://dx.doi.org/10.4161/hv.28950 |
| work_keys_str_mv | AT montefioridavidc importanceofneutralizationsieveanalyseswhenseekingcorrelatesofhiv1vaccineefficacy |