The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

Deregulation of the receptor tyrosine kinase RET has been implicated in medullary thyroid cancer, a small percentage of lung adenocarcinomas, endocrine-resistant breast cancer and pancreatic cancer. There are several clinically approved multi-kinase inhibitors that target RET as a secondary pharmaco...

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Detalles Bibliográficos
Autores principales: Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896931/
https://www.ncbi.nlm.nih.gov/pubmed/26874741
http://dx.doi.org/10.1016/j.ejmech.2016.01.039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896931/
https://www.ncbi.nlm.nih.gov/pubmed/26874741
http://dx.doi.org/10.1016/j.ejmech.2016.01.039

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