Enantioselectivity and Enzyme-Substrate Docking Studies of a Ketoreductase from Sporobolomyces salmonicolor (SSCR) and Saccharomyces cerevisiae (YOL151w)

Models for two ketoreductases were created and used to predict the stereoselectivity of the enzymes. One was based on the crystal structure of Sporobolomyces salmonicolor. This model was used to predict the stereoselectivity for 46 ketone reductions using this enzyme; only 6 were incorrectly predict...

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Detalles Bibliográficos
Autores principales: Nguyen, Phung-Hoang, West, Maya, Feske, Brent D., Padgett, Clifford W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897451/
https://www.ncbi.nlm.nih.gov/pubmed/27350963
http://dx.doi.org/10.1155/2014/124289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897451/
https://www.ncbi.nlm.nih.gov/pubmed/27350963
http://dx.doi.org/10.1155/2014/124289

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