DNA studies are necessary for accurate patient diagnosis in compound heterozygosity for Hb Adana (HBA2:c.179>A) with deletional or nondeletional α-thalassaemia

Haemoglobin (Hb) Adana (HBA2:c.179>A) interacts with deletional and nondeletional α-thalassaemia mutations to produce HbH disorders with varying clinical manifestations from asymptomatic to severe anaemia with significant hepatosplenomegaly. Hb Adana carriers are generally asymptomatic and haemog...

Descripción completa

Detalles Bibliográficos
Autores principales: Tan, Jin Ai Mary Anne, Kho, Siew Leng, Ngim, Chin Fang, Chua, Kek Heng, Goh, Ai Sim, Yeoh, Seoh Leng, George, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897612/
https://www.ncbi.nlm.nih.gov/pubmed/27271331
http://dx.doi.org/10.1038/srep26994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897612/
https://www.ncbi.nlm.nih.gov/pubmed/27271331
http://dx.doi.org/10.1038/srep26994

Ejemplares similares