G2385R and I2020T Mutations Increase LRRK2 GTPase Activity

The LRRK2 mutation is a major causal mutation in familial Parkinson's disease. Although LRRK2 contains functional GTPase and kinase domains and their activities are altered by pathogenic mutations, most studies focused on LRRK2 kinase activity because the most prevalent mutant, G2019S, enhances...

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Detalles Bibliográficos
Autores principales: Ho, Dong Hwan, Jang, Jihoon, Joe, Eun-hye, Son, Ilhong, Seo, Hyemyung, Seol, Wongi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897664/
https://www.ncbi.nlm.nih.gov/pubmed/27314038
http://dx.doi.org/10.1155/2016/7917128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897664/
https://www.ncbi.nlm.nih.gov/pubmed/27314038
http://dx.doi.org/10.1155/2016/7917128

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