Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1

The exceptionally conserved metazoan MAB21 proteins are implicated in cell fate decisions and share considerable sequence homology with the cyclic GMP-AMP synthase. cGAS is the major innate immune sensor for cytosolic DNA and produces the second messenger 2′-5′, 3′-5′ cyclic GMP-AMP. Little is known...

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Detalles Bibliográficos
Autores principales: de Oliveira Mann, Carina C., Kiefersauer, Reiner, Witte, Gregor, Hopfner, Karl-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897736/
https://www.ncbi.nlm.nih.gov/pubmed/27271801
http://dx.doi.org/10.1038/srep27498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897736/
https://www.ncbi.nlm.nih.gov/pubmed/27271801
http://dx.doi.org/10.1038/srep27498

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