Design, biological evaluation and 3D QSAR studies of novel dioxin-containing pyrazoline derivatives with thiourea skeleton as selective HER-2 inhibitors

A series of novel dioxin-containing pyrazoline derivatives with thiourea skeleton have been designed, synthesized and evaluated for their EGFR/HER-2 inhibitory and anti-proliferation activities. A majority of them displayed selective HER-2 inhibitory activity against EGFR inhibitory activity. Compou...

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Detalles Bibliográficos
Autores principales: Yang, Bing, Yang, Yu-Shun, Yang, Na, Li, Guigen, Zhu, Hai-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897788/
https://www.ncbi.nlm.nih.gov/pubmed/27273260
http://dx.doi.org/10.1038/srep27571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897788/
https://www.ncbi.nlm.nih.gov/pubmed/27273260
http://dx.doi.org/10.1038/srep27571

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