Interleukin-1β induced Stress Granules Sequester COX-2 mRNA and Regulates its Stability and Translation in Human OA Chondrocytes

Enhanced and immediate expression of cyclooxygenase-2 (COX-2) mRNA is observed in IL-1β-stimulated OA chondrocytes but the synthesis of protein found significantly delayed. Here we investigated the role of stress granules (SGs), ribonucleoprotein complexes that regulate mRNA translation, in the dela...

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Detalles Bibliográficos
Autores principales: Ansari, Mohammad Y., Haqqi, Tariq M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897887/
https://www.ncbi.nlm.nih.gov/pubmed/27271770
http://dx.doi.org/10.1038/srep27611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897887/
https://www.ncbi.nlm.nih.gov/pubmed/27271770
http://dx.doi.org/10.1038/srep27611

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