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Strong preference of BRCA1 protein to topologically constrained non-B DNA structures

BACKGROUND: The breast and ovarian cancer susceptibility gene BRCA1 encodes a multifunctional tumor suppressor protein BRCA1, which is involved in regulating cellular processes such as cell cycle, transcription, DNA repair, DNA damage response and chromatin remodeling. BRCA1 protein, located primari...

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Detalles Bibliográficos
Autores principales: Brázda, Václav, Hároníková, Lucia, Liao, Jack C. C., Fridrichová, Helena, Jagelská, Eva B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898351/
https://www.ncbi.nlm.nih.gov/pubmed/27277344
http://dx.doi.org/10.1186/s12867-016-0068-6