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Helper virus-mediated downregulation of transgene expression permits production of recalcitrant helper-dependent adenoviral vector

Helper-dependent adenoviral vectors (HDAd) that express certain transgene products are impossible to produce because the transgene product is toxic to the producer cells, especially when made in large amounts during vector production. Downregulating transgene expression from the HDAd during vector p...

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Detalles Bibliográficos
Autores principales: Palmer, Donna J, Grove, Nathan C, Ng, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898405/
https://www.ncbi.nlm.nih.gov/pubmed/27331077
http://dx.doi.org/10.1038/mtm.2016.39