Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(iii) and Eu(iii) ions for specific sensing of a viral RNA

Rational modification of a natural RNA-binding peptide with a lanthanide EDTA chelator, and a phenanthroline ligand yields a highly selective luminescent sensor. The sensing mechanism relies on the RNA-triggered folding of the peptide into a β-hairpin, which promotes the coordination of the phenanth...

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Detalles Bibliográficos
Autores principales: Penas, Cristina, Mascareñas, José L., Vázquez, M. Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898589/
https://www.ncbi.nlm.nih.gov/pubmed/27293537
http://dx.doi.org/10.1039/c5sc04501k
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author Penas, Cristina
Mascareñas, José L.
Vázquez, M. Eugenio
author_facet Penas, Cristina
Mascareñas, José L.
Vázquez, M. Eugenio
author_sort Penas, Cristina
collection PubMed
description Rational modification of a natural RNA-binding peptide with a lanthanide EDTA chelator, and a phenanthroline ligand yields a highly selective luminescent sensor. The sensing mechanism relies on the RNA-triggered folding of the peptide into a β-hairpin, which promotes the coordination of the phenanthroline sensitizer, and the efficient sensitization of complexed lanthanide ions.
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spelling pubmed-48985892016-06-08 Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(iii) and Eu(iii) ions for specific sensing of a viral RNA Penas, Cristina Mascareñas, José L. Vázquez, M. Eugenio Chem Sci Chemistry Rational modification of a natural RNA-binding peptide with a lanthanide EDTA chelator, and a phenanthroline ligand yields a highly selective luminescent sensor. The sensing mechanism relies on the RNA-triggered folding of the peptide into a β-hairpin, which promotes the coordination of the phenanthroline sensitizer, and the efficient sensitization of complexed lanthanide ions. Royal Society of Chemistry 2016-04-01 2016-01-11 /pmc/articles/PMC4898589/ /pubmed/27293537 http://dx.doi.org/10.1039/c5sc04501k Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Penas, Cristina
Mascareñas, José L.
Vázquez, M. Eugenio
Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(iii) and Eu(iii) ions for specific sensing of a viral RNA
title Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(iii) and Eu(iii) ions for specific sensing of a viral RNA
title_full Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(iii) and Eu(iii) ions for specific sensing of a viral RNA
title_fullStr Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(iii) and Eu(iii) ions for specific sensing of a viral RNA
title_full_unstemmed Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(iii) and Eu(iii) ions for specific sensing of a viral RNA
title_short Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(iii) and Eu(iii) ions for specific sensing of a viral RNA
title_sort coupling the folding of a β-hairpin with chelation-enhanced luminescence of tb(iii) and eu(iii) ions for specific sensing of a viral rna
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898589/
https://www.ncbi.nlm.nih.gov/pubmed/27293537
http://dx.doi.org/10.1039/c5sc04501k
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AT vazquezmeugenio couplingthefoldingofabhairpinwithchelationenhancedluminescenceoftbiiiandeuiiiionsforspecificsensingofaviralrna

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