Cargando…

CD5-mediated inhibition of TCR signaling proceeds normally in the absence of SHP-1

The CD5 transmembrane glycoprotein functions as a co-receptor in the signaling pathway linking T-cell antigen receptor (TCR) engagement to activation and differentiation. Although CD5 effects on TCR signaling have been shown to be primarily inhibitory, the underlying mechanisms remain unclear. In vi...

Descripción completa

Detalles Bibliográficos
Autores principales:	DONG, BAOXIA, SOMANI, ALLY-KHAN, LOVE, PAUL E., ZHENG, XUAN, CHEN, XIEQUN, ZHANG, JINYI
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899029/ https://www.ncbi.nlm.nih.gov/pubmed/27221212 http://dx.doi.org/10.3892/ijmm.2016.2592

Ejemplares similares

THEMIS enhances TCR signaling and enables positive selection by selective inhibition of SHP-1
por: Choi, Seeyoung, et al.
Publicado: (2017)

CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity
por: Azzam, Hala S., et al.
Publicado: (1998)

Purity of transferred CD8(+) T cells is crucial for safety and efficacy of combinatorial tumor immunotherapy in the absence of SHP-1
por: Watson, H Angharad, et al.
Publicado: (2016)

Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms
por: Presotto, Danilo, et al.
Publicado: (2017)

Sidestepping SHP2 inhibition
por: Popescu, Bogdan, et al.
Publicado: (2023)

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
por: Bunda, Severa, et al.
Publicado: (2015)

The Transmembrane Adaptor Protein SIT Inhibits TCR-Mediated Signaling
por: Arndt, Börge, et al.
Publicado: (2011)

CD8(+) T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine
por: Cho, Hyoung-Soo, et al.
Publicado: (2020)

CD5, an Undercover Regulator of TCR Signaling
por: Voisinne, Guillaume, et al.
Publicado: (2018)

Binding of Staphylococcal Enterotoxin B (SEB) to B7 Receptors Triggers TCR- and CD28-Mediated Inflammatory Signals in the Absence of MHC Class II Molecules
por: Kunkl, Martina, et al.
Publicado: (2021)

Selective inhibition of leukemia-associated SHP2(E69K) mutant by the allosteric SHP2 inhibitor SHP099
por: Sun, X, et al.
Publicado: (2018)

Lck Mediates Signal Transmission from CD59 to the TCR/CD3 Pathway in Jurkat T Cells
por: Lipp, Anna M., et al.
Publicado: (2014)

miR-20a Inhibits TCR-Mediated Signaling and Cytokine Production in Human Naïve CD4(+) T Cells
por: Reddycherla, Amarendra V., et al.
Publicado: (2015)

Potentiating CD8(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling
por: Yuan, Juanjuan, et al.
Publicado: (2021)

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules
Publicado: (1989)

PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors
por: Isakov, Noah, et al.
Publicado: (2012)

CD45-mediated control of TCR tuning in naïve and memory CD8(+) T cells
por: Cho, Jae-Ho, et al.
Publicado: (2016)

Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains
Publicado: (1994)

Inhibition of SHP2 and SHP1 Protein Tyrosine Phosphatase Activity by Chemically Induced Dimerization
por: Buck, Sara J. S., et al.
Publicado: (2022)

Surface expression of a T cell receptor beta (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins
Publicado: (1991)

Synergistic Efficacy of the Demethylation Agent Decitabine in Combination With the Protease Inhibitor Bortezomib for Treating Multiple Myeloma Through the Wnt/β-Catenin Pathway
por: Jin, Yulong, et al.
Publicado: (2019)

Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection
Publicado: (1995)

Correction to: Potentiating CD8(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling
por: Yuan, Juanjuan, et al.
Publicado: (2021)

Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
por: Zhang, Tao, et al.
Publicado: (2016)

The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain
por: Kirchgessner, Henning, et al.
Publicado: (2001)

Rgg-Associated SHP Signaling Peptides Mediate Cross-Talk in Streptococci
por: Fleuchot, Betty, et al.
Publicado: (2013)

SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction
por: Kan, Chen, et al.
Publicado: (2018)

Commitment of Immature CD4(+)8(+) Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains
por: Suzuki, Harumi, et al.
Publicado: (1997)

Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4(+) T cell homeostasis
por: Borlido, Joana, et al.
Publicado: (2018)

Correction to: Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
por: Zhang, Tao, et al.
Publicado: (2018)

Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8(+) but not CD4(+) T cells
por: Sasai, Miwa, et al.
Publicado: (2021)

IGSF4 is a novel TCR ζ-chain–interacting protein that enhances TCR-mediated signaling
por: Kim, Hye-Ran, et al.
Publicado: (2011)

Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex
Publicado: (1991)

Neoantigen-specific TCR-T cell-based immunotherapy for acute myeloid leukemia
por: Zhou, Weijun, et al.
Publicado: (2022)

Normalized Synergy Predicts That CD8 Co-Receptor Contribution to T Cell Receptor (TCR) and pMHC Binding Decreases As TCR Affinity Increases in Human Viral-Specific T Cells
por: Williams, Chad M., et al.
Publicado: (2017)

Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization
por: Xu, Zhiyong, et al.
Publicado: (2021)

Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ((+))CD8αα((+)) intraepithelial lymphocytes
por: Grandjean, Capucine L., et al.
Publicado: (2017)

Cish attenuates proximal TCR-signaling and CD8+ T cell immunity
por: Palmer, Douglas, et al.
Publicado: (2014)

The role of the different CD3γ domains in TCR expression and signaling
por: Garcillán, Beatriz, et al.
Publicado: (2022)

SHP-2 Interacts with CD81 and Regulates the Malignant Evolution of Colorectal Cancer by Inhibiting Epithelial–Mesenchymal Transition
por: Yuan, Huaqin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_in98l2g3mtn2ti1go5o4r98inb