Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?

Molecules of mitochondrial cardiolipin (CL) get selectively oxidized upon oxidative stress, which triggers the intrinsic apoptotic pathway. In a chemical model most closely resembling the mitochondrial membrane—liposomes of pure bovine heart CL—we compared ubiquinol-10, ubiquinol-6, and alpha-tocoph...

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Detalles Bibliográficos
Autores principales: Lokhmatikov, Alexey V., Voskoboynikova, Natalia, Cherepanov, Dmitry A., Skulachev, Maxim V., Steinhoff, Heinz-Jürgen, Skulachev, Vladimir P., Mulkidjanian, Armen Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899610/
https://www.ncbi.nlm.nih.gov/pubmed/27313834
http://dx.doi.org/10.1155/2016/8679469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899610/
https://www.ncbi.nlm.nih.gov/pubmed/27313834
http://dx.doi.org/10.1155/2016/8679469

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