Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1

A common genetic form of Parkinson's disease (PD) is caused by mutations in LRRK2. We identify WSB1 as a LRRK2 interacting protein. WSB1 ubiquitinates LRRK2 through K27 and K29 linkage chains, leading to LRRK2 aggregation and neuronal protection in primary neurons and a Drosophila model of G201...

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Detalles Bibliográficos
Autores principales: Nucifora, Frederick C., Nucifora, Leslie G., Ng, Chee-Hoe, Arbez, Nicolas, Guo, Yajuan, Roby, Elaine, Shani, Vered, Engelender, Simone, Wei, Dong, Wang, Xiao-Fang, Li, Tianxia, Moore, Darren J., Pletnikova, Olga, Troncoso, Juan C., Sawa, Akira, Dawson, Ted M., Smith, Wanli, Lim, Kah-Leong, Ross, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899630/
https://www.ncbi.nlm.nih.gov/pubmed/27273569
http://dx.doi.org/10.1038/ncomms11792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899630/
https://www.ncbi.nlm.nih.gov/pubmed/27273569
http://dx.doi.org/10.1038/ncomms11792

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