Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2

Cholinergic impairments and tau accumulation are hallmark pathologies in sporadic Alzheimer’s disease (AD), however, the intrinsic link between tau accumulation and cholinergic deficits is missing. Here, we found that overexpression of human wild-type full-length tau (termed hTau) induced a signific...

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Detalles Bibliográficos
Autores principales: Yin, Yaling, Wang, Yali, Gao, Di, Ye, Jinwang, Wang, Xin, Fang, Lin, Wu, Dongqin, Pi, Guilin, Lu, Chengbiao, Zhou, Xin-Wen, Yang, Ying, Wang, Jian-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899694/
https://www.ncbi.nlm.nih.gov/pubmed/27277673
http://dx.doi.org/10.1038/srep27283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899694/
https://www.ncbi.nlm.nih.gov/pubmed/27277673
http://dx.doi.org/10.1038/srep27283

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