Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis

Serum levels of the lipid mediator sphingosine-1-phosphate (S1P) are reduced in septic patients and are inversely associated with disease severity. We show that serum S1P is reduced in human sepsis and in murine models of sepsis. We then investigated whether pharmacological or genetic approaches tha...

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Detalles Bibliográficos
Autores principales: Coldewey, Sina M., Benetti, Elisa, Collino, Massimo, Pfeilschifter, Josef, Sponholz, Christoph, Bauer, Michael, Huwiler, Andrea, Thiemermann, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899780/
https://www.ncbi.nlm.nih.gov/pubmed/27277195
http://dx.doi.org/10.1038/srep27594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899780/
https://www.ncbi.nlm.nih.gov/pubmed/27277195
http://dx.doi.org/10.1038/srep27594

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