Cargando…

Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis

Serum levels of the lipid mediator sphingosine-1-phosphate (S1P) are reduced in septic patients and are inversely associated with disease severity. We show that serum S1P is reduced in human sepsis and in murine models of sepsis. We then investigated whether pharmacological or genetic approaches tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coldewey, Sina M., Benetti, Elisa, Collino, Massimo, Pfeilschifter, Josef, Sponholz, Christoph, Bauer, Michael, Huwiler, Andrea, Thiemermann, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899780/ https://www.ncbi.nlm.nih.gov/pubmed/27277195 http://dx.doi.org/10.1038/srep27594

Ejemplares similares

Enhanced sphingosine-1-phosphate levels ameliorate murine septic cardiomyopathy
por: Coldewey, SM, et al.
Publicado: (2015)

Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse
por: Coldewey, Sina M., et al.
Publicado: (2013)

Baricitinib protects mice from sepsis-induced cardiac dysfunction and multiple-organ failure
por: Verra, Chiara, et al.
Publicado: (2023)

Gender Dimorphism of the Cardiac Dysfunction in Murine Sepsis: Signalling Mechanisms and Age-Dependency
por: Chen, Jianmin, et al.
Publicado: (2014)

Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the β-common receptor
por: Khan, Areeg I., et al.
Publicado: (2013)

Cardiovascular impairment in Shiga-toxin-2-induced experimental hemolytic–uremic syndrome: a pilot study
por: Neu, Charles, et al.
Publicado: (2023)

Editorial: Community series in translational insights into mechanisms and therapy of organ dysfunction in sepsis and trauma, volume II
por: Relja, Borna, et al.
Publicado: (2023)

Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow
por: Bangash, Mansoor N, et al.
Publicado: (2013)

Inhibition of Bruton’s Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats
por: Patel, Nikita M., et al.
Publicado: (2023)

Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice
por: O'Riordan, Caroline E., et al.
Publicado: (2019)

Inhibition of the JAK/STAT Pathway With Baricitinib Reduces the Multiple Organ Dysfunction Caused by Hemorrhagic Shock in Rats
por: Patel, Nikita M., et al.
Publicado: (2023)

Sphingosine-1-Phosphate Receptor-2 Antagonists: Therapeutic Potential and Potential Risks
por: Blankenbach, Kira V., et al.
Publicado: (2016)

Decreased serum concentrations of sphingosine-1-phosphate in sepsis
por: Winkler, Martin Sebastian, et al.
Publicado: (2015)

Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge
por: Stepanovska, Bisera, et al.
Publicado: (2020)

Sphingosine-1-phosphate is a novel biomarker in sepsis severity
por: Nierhaus, A, et al.
Publicado: (2015)

The synthetic antimicrobial peptide 19-2.5 attenuates septic cardiomyopathy and prevents down-regulation of SERCA2 in polymicrobial sepsis
por: Martin, Lukas, et al.
Publicado: (2016)

Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-κB
por: Al Zoubi, Sura, et al.
Publicado: (2018)

Plasma Sphingosine-1-Phosphate Is Elevated in Obesity
por: Kowalski, Greg M., et al.
Publicado: (2013)

X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure
por: O'Riordan, Caroline E., et al.
Publicado: (2020)

Sphingosine-1-phosphate is a new biomarker for severity in human sepsis
por: Winkler, MS, et al.
Publicado: (2015)

Bruton’s tyrosine kinase inhibition attenuates disease progression by reducing renal immune cell invasion in mice with hemolytic-uremic syndrome
por: Kröller, Sarah, et al.
Publicado: (2023)

RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance
por: Chen, Jianmin, et al.
Publicado: (2020)

Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infection
por: Winkler, Martin Sebastian, et al.
Publicado: (2021)

Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shock
por: Nandra, Kiran K., et al.
Publicado: (2013)

A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke
por: Lucaciu, Alexandra, et al.
Publicado: (2020)

Sphingosine 1-phosphate levels in cerebrospinal fluid after subarachnoid hemorrhage
por: Männer, Anika, et al.
Publicado: (2020)

Sphingosine 1-Phosphate Receptor 5 (S1P(5)) Knockout Ameliorates Adenine-Induced Nephropathy
por: Eckes, Timon, et al.
Publicado: (2022)

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia
por: Dobierzewska, Aneta, et al.
Publicado: (2016)

Sphingosine-1 phosphate promotes thymic atrophy during sepsis progression
por: Kuchler, L, et al.
Publicado: (2014)

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer
por: Xu, Guangmeng, et al.
Publicado: (2021)

Serum Sphingosine‐1‐Phosphate Is Decreased in Patients With Acute‐on‐Chronic Liver Failure and Predicts Early Mortality
por: Mücke, Victoria T., et al.
Publicado: (2020)

Serum sphingolipidomic analyses reveal an upregulation of C16- ceramide and sphingosine-1-phosphate in hepatocellular carcinoma
por: Grammatikos, Georgios, et al.
Publicado: (2016)

Erythropoietin in the intensive care unit: beyond treatment of anemia
por: Patel, Nimesh SA, et al.
Publicado: (2011)

Sphingosine 1-phosphate escapes the Catch-22 of sepsis prevention and mitigation therapies
por: Blaho, Victoria A.
Publicado: (2020)

Role of sphingosine 1-phosphate (S1P) in sepsis-associated intestinal injury
por: Sun, Gehui, et al.
Publicado: (2023)

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis
por: Masuda-Kuroki, Kana, et al.
Publicado: (2023)

Sphingosine 1‐phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons
por: Frej, Cecilia, et al.
Publicado: (2016)

Sphingosine 1-Phosphate and Atherosclerosis
por: Kurano, Makoto, et al.
Publicado: (2018)

Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism
por: Gläser, Anne, et al.
Publicado: (2020)

The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection
por: Imre, Gergely, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_idla34sdj7874uctnjref85kbc